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DISCUSSION # 1 Reply to Reesha Acute and Chronic Pancreatitis

Acute Pancreatitis

· Acute condition of diffuse pancreatic inflammation & autodigestion, presents with abdominal pain, and is usually associated with raised pancreatic enzyme levels in the blood & urine.

· Reversible inflammation of the pancreas

· Ranges from mild to severe

Differentia Diagnosis:

· Perforated bowel

· Acute cholecystitis

· Acute intestinal obstruction

· Signs & Symptoms of Acute

· Upper Abdominal pain, sudden onset, sharp, severe, continuous, radiates to the back, reduced by leaning forward.Generalized abdominal pain, radiates to the shoulder tips.Patient lies very still.

· Nausea, non-projectile vomiting, retching

· Anorexia

· Fever, weakness

· Distressed, moving continuously, or sitting still

· Pale, diaphoretic. Confusion

· Low grade fever

· Tachycardia, Tachypnea

· Shallow breathing

· Hypotension

· Mild icterus

· Abdominal distension (Ileus, Ascites)

· Grey Turner's sign, Cullen's sign, Fox's sign

· Rebound tenderness, Rigidity

· Shifting dullness, reduced bowel sounds

· Treatment Modalities

· Aggressive supportive care

· Decrease inflammation

· Limit superinfection

· Identify and treat complications (of pancreatitis & its treatment)

· Treat cause if possible

· Give analgesics (IM pethidine).

· Give antiemetics.

· Keep the patient NPO (until pain free/2-3 days).

· NGT insertion to relieve vomiting

Patient and/or Family Teaching and Information

· Explain what pancreatitis is and its causes

· What are the signs and symptoms

· Explain how acute pancreatitis is treated

· Lifestyle modifications

· Chronic pancreatitis is a progressive inflammatory disorder that leads to irreversible destruction of exocrine and endocrine pancreatic parenchyma caused by atrophy and/ or replacement with fibrotic tissue.

· Alcohol consumption, nicotine habits, nutrition, hereditary, well characterized mutations, ductal obstruction and autoimmune factors can contribute to the diagnosis of CP (Brock, et, al., 2013).

· Functional consequences include:

· severe abdominal pain

· diabetes mellitus

· malabsorption

Chronic pancreatitis

· Chronic pancreatitis is a progressive inflammatory disorder that leads to irreversible destruction of exocrine and endocrine pancreatic parenchyma caused by atrophy and/ or replacement with fibrotic tissue.

· Alcohol consumption, nicotine habits, nutrition, hereditary, well characterized mutations, ductal obstruction and autoimmune factors can contribute to the diagnosis of CP (Brock, et, al., 2013).

· Functional consequences include:

· severe abdominal pain

· diabetes mellitus

· malabsorption

· The pancreas is an accessory organ that functions in the endocrine and exocrine systems

· Responsible for hydrolysis of proteins, carbohydrates, and fats

· The pancreas has a main pancreatic duct running through the length of it, an accessory duct, and many various cell types.

· The ducts can become blocked, or they can be genetically deformed

· During constant inflammation, scarring and fibrosis of the ducts lead to permanent damage to many structures, impairing its secretory functions.

Treatment Methodologies

· Goal of treatment is to decrease abdomen pain and malabsorption

· Enzyme replacement treatment and dietary modification

· Non-opioid regimens should be utilized (TCA, NSAIDs, pregabalin)

· New studies show some benefit of using medium-chain triglycerides (Benjamin & Lappin, 2022).

· During breakthrough uncontrollable pain hospitalization may be necessary

· Decompression surgery can be considered in those with intractable pain who have failed medical therapy

·

Differential Diagnosis

. Pancreatic Cancer

2. Cholelithiasis

3. Peptic Ulcer Disease

Patient and Family Teaching

· Eating small, frequent low-fat meals

· A low-fat diet with high protein and carbohydrates is recommended for patients with steatorrhea

· Fat intake should be less than 20g/day or less

· Oral supplementation of fat-soluble vitamins

· Replacement of fat-soluble vitamins and pancreatic enzymes

· Cut out all consumption of alcohol and all forms of tobacco

· Patients who continue to drink alcohol, have a death rate 3 times higher than those who do not drink alcohol

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