Ccompare zerbaxa and other drugs like 1- microbiological activity between ceftolozane/Tazobactam, ceftazidime , meropenem, and piperaciilin/ tazobactam against pseudomonas aeroginosa insolated from children with cystic fibrosis by Kuti (2015). 2- Comparison of ceftazidime/ avibactam and ceftolozane/tazobactam in vitro activities when tested gram negative bacteria isolated from patients hospitalzed with pneumonia by sader (2020) 3- ceftolozane/ tazobactam versus meropenem for treatment of nosocomial pneumonia: Randomized, controlled, double blind phase 3 non-inferiority trail by kollef (2019)